Robert C. Olby Collection
1951-1963
(0.25 linear feet)

B OL1

© American Philosophical Society
105 South Fifth Street * Philadelphia, PA 19106-3386

American Philosophical Society

105 South Fifth Street
Philadelphia, PA 19106-3386
Table of contents Abstract
The historian of science Robert C. Olby is a graduate of University College London and Oxford. Best known for his work on the history of genetics, especially the Bateson school, and for his study of the early history of molecular biology, Olby is currently a Research Professor in the History and Philosophy of Science at the University of Pittsburgh. He is the author of The Origins of Mendelism (1966), Charles Darwin (1967), The Path to the Double Helix (1994), and the Norton History of Biology. His current research is focused on the conceptual foundations of modern sensory neurophysiology and an intellectual biography of Francis Crick.

The Olby Collection contains about 150 photocopies of correspondence and documents collected by Olby during research for The Path to the Double Helix. Among these is a copy of a manuscript by F. C. Crick and James D. Watson, "The Complementary Structure of Deoxyribonucleic Acid," prepared while Watson was at CalTech.
Background note
A graduate of the University College London and Oxford, Robert C. Olby (b. 1933) earned a reputation as an innovative historian of genetics with the publication of first book The Origins of Mendelism in 1966. When a former undergraduate friend of his, John Preble, suggested that he study the history of molecular biology, Olby gained an introduction to Francis Crick, the British biophysicist and co-discoverer of the structure of DNA, who became both a scientific informant and close friend. Olby's The Path to the Double Helix (1974) provided an overview of the intellectual and institutional background that resulted in Watson and Crick's "physical and chemical account of the gene." In his introduction, Olby stated simply that his hope was that the book would "afford the historian, sociologist and scientist a guide to the source material relating to the origins of molecular biology, with special reference to DNA," but in fact it presented a masterful use of both primary written sources and oral histories. Ironically, Olby claimed that as a student at the University College London in the fifties, he could not remember hearing the word DNA ever being uttered.

Olby taught history of science at the University of Leeds from 1969-1993 and in the department of the History and Philosophy of Science at the University of Pittsburgh from 1994-2001, where he remains as Research Professor.


Scope and content
The Olby Collection (23 folders, ca.97 items) is comprised almost entirely of photocopies of correspondence from scientists involved in the discovery of the double helical structure of DNA in 1953. The correspondents include Sydney Brenner, Francis Crick, Max Delbruck, Rosalind Franklin, Roger Herriott, Alfred Hershey, Salvadore Luria, Marshall Matthaei, Mathew Meselson, Linus Pauling, Alexander Rich, and James Watson. The topics discussed within the correspondence include but are not limited to the structure of DNA, Pauling's theory, RNA backbone, Jonathan Warner, and the RNA central code.

Administrative information
Restrictions
None.

Provenance
Gift of Robert C. Olby, June 1969 and October 1970 (acc. No. 1976-344ms and 1976-345ms).

Preferred citation
Cite as: Robert C. Olby Collection, American Philosophical Society.

Other finding aids
The Robert Olby Papers are briefly described in Bentley Glass's A Guide to the Genetics Collections of the APS.

Additional information
References
Olby, Robert C., The Origins of Mendelism (London: Constable, 1966). Call no.: 575.1 OL1o.

Olby, Robert C., The Path to the Double Helix (Seattle: Univ. of Washington, 1974). Call no.: 574.19 OL1p.

Added entries
Subjects
  • DNA--Structure
  • Genetics
  • Molecular biology--History
  • Contributors
  • Brenner, Sydney
  • Crick, Francis, 1916-
  • Delbruck, Max
  • Franklin, Rosalind, 1920-1958
  • Gamow, George, 1904-1968
  • Herriott, Roger Moss, 1908-
  • Hershey, A. D. (Alfred Day), 1908-1997
  • Luria, S. E. (Salvador Edward), 1912-
  • Matthaei, Heinrich
  • Nirenberg, Marshall W.
  • Olby, Robert C. (Robert Cecil), 1933-
  • Pauling, Linus, 1901-1994
  • Rich, Alexander
  • Watson, James D., 1928-
  • Contact information
    American Philosophical Society
    105 South Fifth Street
    Philadelphia, PA 19106-3386

    [http://www.amphilsoc.org/]

    ©6/2003

      Sponsor:Encoding made possible by a grant by the Pew Foundation

    Detailed inventory

    Brenner, Sydney, TLS Cy to Matthew Meselson 1960 May 7 1 item

    Recent Monod-Jacob work.


    Crick, Francis, Folder 1 1955-1956 6 items

    Existance of deoxy-uracil in DNA; experiments on Collagen; new structure for polyglycine.


    Crick, Francis, Folder 2 1957-1960 7 items

    Polynucleotides; poly A; poly I + poly C; angle of hydroge hydrogen bond; DNA and RNA.


    Crick, Francis, Folder 3. TLS Cy to Alex Rich 1963 April 24 1 item

    Re: Rich's manuscript for Nature


    Crick, Francis and J. D. Watson, The Complimentary Structure of Deoxyribonucleic Acid n.d. 28 pp.

    Delbruck, Max, Folder 1. TLS Cy to J. D. Watson 1953 April 14 1 item

    DNA structure


    Delbruck, Max, Folder 2. TLS Cy to Alex and Jane Rich 1955 November 9 1 item

    Rundle's RNA structure


    Franklin, Rosalind, ALS Cy to Alex Rich 1958 March 16 1 item

    TMV


    Gamow, George, Folder 1. ALS Cy to Alex Rich 1955-1956 8 items

    Discusses his book; trouble with proteins; divorce; research questions; official club circular; hellix vs. solenoid entanglement of chromosomes.


    Gamow, George , Folder 2. ALS Cy to Alex Rich 1958-1962 5 items

    On writing books; son Jgor; soliciting opinion on the latest pronouncement by Francis Crick, Barnett, Brenner, and Watts-Tobin concerning "The General Nature of the Genetic Code."


    Herriott, Roger M. , TLS Cy to Alfred D. Hershey 1951 November 16 1 item

    Amino acids in the phage but not in the ghosts; centrifugation of the ghosts; his own virus problem.


    Hershey, Alfred D. , TL Cy to Roger M. Herriott 1951 November 20 1 item

    Results of the S 35 experiments; addressing Herriott's idea about the nucleic acid and Hershey's own opinion about intracellular phage.


    Luria, Salvadore , 1952-1953 2 items

    S35 and protein and DNA; Pauling's theory.


    Matthaei, Marshall, n.d. - 1960 8 items

    Materials obtained by Heinrich Matthaei, a coworker with Drl Marshall Nirenberg, who won the Nobel prize for the discovery of DNA and collected by Olby for his book, The Path to the Double Helix


    Meselson, Mathew, TL Cy to Sydny Brenner and F. Jacob 1961 February 15 1 item

    Regarding The Unstable Intermediatemanuscript


    Pauling, Linus, TLS Cy to Dr. James Watson 1953 March 5 1 item

    Protein conference and Pauling's new structure for the nucleic acids.


    Rich, Alexander, Folder 1 1956-1957 8 items

    RNA backbone; WC structure for DNA; p32 labelling; measurements on various muscle protein fractions; the prospect of DNA's coding for RNA; collagen model; DNA synthesizing system; creating new polymers;


    Rich, Alexander, Folder 2. TL Cy to F. H. C. Crick 1957-1961 7 items

    System polyinosinic acid plus polycytidylic acid; poly A coordinates; Russian collagen article; Maurice's DNA coordinates; Pauling-Coring models; Nirenberg system;


    Rich, Alexander, Folder 3. TL Cy to F. H. C. Crick 1962-1963 3 items

    Jonathan Warner; polyribosomes; mixed crystals; NMR study of cytidine and deoxycitidine; structure of the guanine-cytosine crystal; finding another complex; in vitro incubation experiments with polyribosomes.


    Summary of Events Leading to Solution of DNA Structure , n.d. 1 item

    10-page timeline.


    Watson, James D., Folder 1 1953 March 2 items

    Pauling's seminar.


    Watson, James D. , Folder 2. ALS Cy to Alex Rich 1955 March 9 1 item

    RNA central code


    Watson, James D. , Miscellaneous Notes n.d. 2 items